Superoxide Dismutases (SODs), also known as manganese-dependent superoxide dismutase (MnSOD, SOD2), were initially discovered as indophenoloxidases (IPOs) which are endogenously-produced intracellular antioxidant enzymes that catalyze the conversion of superoxide radical anions produced from oxidative phosphorylation into hydrogen peroxide (H2O2) and further catalyzed to innocuous oxygen (O2) and water (H2O) by glutathione peroxidase and catalase. Broadly this serves as a defense mechanism against reactive oxygen species (ROS).
SOD2 is a homotetramer with a mass of 80 kDa and is a manganese-containing enzyme residing in the mitochondrial matrix near proximity to the mitochondrial respiratory chain, which serves as the primary endogenous source for superoxide. Three isoenzymes of SOD have been identified, though are related in functionality, vary widely in homology ranging from 17-23% between SOD1 which contains Cu and Zn ions as a homodimer existing in the cytoplasm where two 16 kDa subunits are linked by two cysteines forming an intra-subunit disulphide bridge and SOD3 (EC-SOD) which is a homotetramer of 30 kDa existing only in the extracellular space and can be distinguished by its heparin binding capacity which also contains Cu and Zn ions . However, SOD2's homology is preserved from species to species ranging from 87-90% homology match among rat and mouse SOD2. The vast majority oxidative stress within cells originates from the mitochondrion which is where SOD2 plays a key role in maintaining the structure and function of enzymes and their functionality and in particular, providing a defense mechanism for those enzymes which are susceptible to inactivation by superoxide. In homo sapiens, the SOD2 is encoded by the SOD2 gene residing on chromosome 6 and mutations associated with the SOD2 gene have been indicative of premature aging, sporadic motor neuron disease, idiopathic cardiomyopath (IDC) and cancer.
|Unit of Measure||µg|
|Shelf Life||24 MONTHS|
|Molecular Weight||25 kDa|
|Concentration||Lot-specific, see COA|
|Made In||United States of America|
|Appearance||Clear, colorless liquid|
|Gene ID||SOD2 (6648)|
|Control||Rat brain tissue extract|
|Species||Rat, Human, Bove, Mouse|
|Storage Buffer||PBS, pH 7.2, containing 50% glycerol and 0.1% sodium azide|
|Synonyms||Mn Superoxide Dismutase, Mn SOD, Indophenoloxidase B, Manganese Superoxide Dismutase, Manganese-Containing Superoxide Dismutase, Mangano-Superoxide Dismutase, Superoxide Dismutase 2, SOD2, mitochondrial, P04179, Mn-SOD, MNSOD, MnSOD, IPO-B|
Q. How much is shipping and handling? A. This product is temperature sensitive and does ship on ice. For US customers, S&H charges are $19. For international customers, shipping and handling costs will vary based on location and order size. Additional customs/duties/VAT charges may be incurred for international orders.
Q. How do I place an order? A. All Redoxica products are fulfilled by our exclusive global distribution partner, Labscoop. You can place an order via Labscoop.com, submit your PO by email to firstname.lastname@example.org, by fax at 1.800.316.3081 or by phone at 1.800.316.3081.
Q. How do I find pricing and availability? A. The latest pricing and availability is displayed on our website. This is updated in real-time and is the exact same information that our support team and distributors have access to. If you need a formal quotation, please submit a quote request.
Q. Do you offer any discounts? A. We conduct an extensive price analysis on each product we release, so you can be confident that you are getting a great price when comparing the quality of our products, the quantity, and S&H charges. For bulk orders (quantities over 5), please submit a bulk quote request and in most cases we will be able to offer some discounts. For quantities under 5, unfortunately we do not offer any additional discounts.
Q. I still have questions, how do I contact technical support? A. No problem! Email us directly at email@example.com
FIND A DISTRIBUTOR
STORAGE & SAFETY
2-8°C (KEEP REFRIGERATED, LIGHT SENSITIVE)
Precautions & Disclaimer
For Laboratory Research and Development Use Only. Not for drug, household or other uses.
SHIPPING & HANDLING
Borosilicate Glass Bottle
5" X 5" X 10"